Anne Flournoy's first film Louise Smells A Rat premiered at The New York Film Festival and was picked up for distribution by Kino Intl. Her third film, Nadja Yet, co-starred Jenny Wright (Near Dark), Stephen Payne (Compliance) and a live-action housefly. Variety called it a 'nine-minute showstopper'.

How To Be Louise, Flournoy's first feature, screened in competition at The Sundance Film Festival and in the Panorama at the Berlin International Film Festival.  Lea Floden, Bruce McCarty and Maggie Burke star, Phillip Johnston (Microscopic Quartet) composed the score and Vladimir Tukan was the Director of Photography. Michael Patrick King, the writer/exec producer of Sex In The City, played a cameo as a double-dealing agent.

After rave reviews in the Italian press, How To Be Louise returned to New York and played for a month at Jonas Mekas' Anthology Film Archives. The Sundance Institute has launched it online via itunes, hulu, Sundance Now and amazon. 

In 2007,  Flournoy began producing The Louise Log, a comedy web series about the inner life of a New York City woman. She is a Guggenheim Fellow.